In Vivo Scientist

Fusion Pharmaceuticals, a member of the AstraZeneca Group, is a clinical-stage oncology company focused on developing next-generation radioconjugates (RCs) as precision medicines. Fusion connects alpha particle emitting isotopes to various targeting molecules to selectively deliver the alpha emitting payloads to tumors. Fusion’s clinical portfolio includes but is not limited to: FPI-2265 targeting prostate specific membrane antigen (PSMA) for metastatic castration resistant prostate cancer currently in a Phase 2 trial; FPI-1434 targeting insulin-like growth factor 1 receptor currently in a Phase 1 trial; and FPI-2068, a bispecific IgG-based EGFR-cMET targeted radioconjugate currently in a Phase 1 trial. Fusion has multiple other pipeline programs that will soon be entering into early FIH trials. In addition, Fusion is pursuing combination programs between RCs and other therapeutic modalities including DNA Damage Response Inhibitors (DDRis) and immune-oncology agents. To support execution for these programs, Fusion has a fully operational Good Manufacturing Practice (GMP) compliant state-of-the-art radioconjugate manufacturing facility to meet supply demand for our growing pipeline of RCs.

In Vivo Scientist

Fusion Pharmaceutical is seeking outstanding candidates for an In Vivo Scientist, who will provide strategic and technical expertise in the design and execution of in vivo preclinical studies across therapeutic areas. The candidate will lead and work collaboratively with internal research teams to complete RC development programs. This position is based at Fusion’s laboratories in Hamilton, Ontario, Canada.

Responsibilities

• Design, plan, and conduct mechanisms of action studies, therapeutic efficacy and biodistribution studies on radiopharmaceuticals in rodent models of cancer or other disease indications of interest
• The In Vivo Scientist will be expected to spend time in the lab and vivarium to execute in vivo studies experiments as needed, including cell culture, in-life monitoring, blood sampling, dosing, and ex vivo analysis (e.g. IHC, autoradiography, flow cytometry, biochemical assays)
• Identify and implement new pharmacology models, technologies, and strategies to develop targeted cancer radiotherapies
• Collaborate with cross-functional teams to provide scientific input and design, execute, and interpret studies, provide solution-oriented expertise to support key decision-making
• Mentor and train research staff ensuring regulatory compliance, technical excellence, high quality and documentation of results
• Write and review study protocols and reports, analyze results, present findings, and contribute to authoring manuscripts and regulatory filings
• Work safely and in compliance with radioactive, biohazardous, animal ethics regulations and guidelines
• Foster an environment of collaboration, scientific excellence, open scientific exchange, and deep scientific rigor
• Other duties as required
  
  

Qualifications

• Post-graduate degree in Molecular/Cell Biology, Biology, Biochemistry or related field with 5+ years of preclinical pharmacology experience with a Master’s degree, or 2+ years of experience with a Ph.D. degree
• Experience designing and performing in vivo pharmacology studies for preclinical drug development required (experienced with IV, IP, SC injections, oral gavage, blood collection, tissue dissections); biotech or pharmaceutical industry experience preferred
• Experience with development and validation of preclinical models of disease; oncology experience preferred
• Demonstrated ability to lead and manage concurrent timelines and deliverables, with strong attention to detail and a solution-oriented mindset
• Proven ability to work collaboratively in a cross-functional team, with the ability to communicate effectively with colleagues at all levels
• Strong documentation and record-keeping skills required
• Previous management experience of research staff an asset
• Experience with the safe handling of radioactive and biohazardous materials an asset
  
  

Fusion Pharmaceuticals is an equal opportunity employer that is committed to inclusive, barrier-free recruitment and selection processes, if contacted for an interview, please advise Human Resources if you require accommodation.

All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, or status as a protected veteran.